ORF30 and ORF34 are essential for expression of late genes in murine gammaherpesvirus 68.

@article{Wu2009ORF30AO,
  title={ORF30 and ORF34 are essential for expression of late genes in murine gammaherpesvirus 68.},
  author={Ting-ting Wu and Tina Park and Hana Kim and T. Tran and Leming Tong and Deeann Martinez-Guzman and Nichole Reyes and Hongyu Deng and Ren Sun},
  journal={Journal of virology},
  year={2009},
  volume={83 5},
  pages={2265-73}
}
A hallmark of productive infection by DNA viruses is the coupling of viral late gene expression to genome replication. Here we report the identification of open reading frame 30 (ORF30) and ORF34 as viral trans factors crucial for activating late gene transcription following viral DNA replication during lytic infection of murine gammaherpesvirus 68 (MHV-68). The mutant virus lacking either ORF30 or ORF34 underwent normal DNA replication but failed to express viral late gene transcripts, leading… CONTINUE READING

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