ORC1 interacts with c-Myc to inhibit E-box-dependent transcription by abrogating c-Myc-SNF5/INI1 interaction.

@article{Takayama2000ORC1IW,
  title={ORC1 interacts with c-Myc to inhibit E-box-dependent transcription by abrogating c-Myc-SNF5/INI1 interaction.},
  author={Masaharu Takayama and Takahiro Taira and Katsuyuki Tamai and Sanae M. M. Iguchi-Ariga and Hiroyoshi Ariga},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2000},
  volume={5 6},
  pages={481-90}
}
BACKGROUND The c-myc oncogene product (c-Myc) is a transcription factor that forms a complex with Max and recognizes the E-box sequence. c-Myc plays key functions in cell proliferation, differentiation and apoptosis. As for its activity towards cell proliferation, it is generally thought that c-Myc transactivates the E-box-containing genes that encode… CONTINUE READING