ORAI3 contributes to hypoxia-inducible factor 1/2α-sensitive colon cell migration.

  title={ORAI3 contributes to hypoxia-inducible factor 1/2$\alpha$-sensitive colon cell migration.},
  author={Dan Zhu and Ren He and W. Yu and C Li and Haoran Cheng and Baoliang Zhu and J Yan},
  journal={Physiology international},
  • D. Zhu, R. He, J. Yan
  • Published 22 June 2021
  • Biology, Medicine
  • Physiology international
Background Hypoxia is a pivotal initiator of tumor angiogenesis and growth through the stabilization of hypoxia-inducible factors (HIFs). This study set out to examine the involvement of HIF-1α and HIF-2α in colon cancer and ascertained whether ORAI3 was involved in the pathway. Materials and methods Patients and murine models as well as human colorectal adenocarcinoma tumor (CW2) cells were included to examine the levels of ORAI1/3 and HIF-1/2α levels. Calcium imaging was utilized to… 

Role of Orai3 in the Pathophysiology of Cancer

Orai3 overexpression is associated with supporting several cancer hallmarks, including cell cycle progression, proliferation, migration, and apoptosis resistance, in prostate cancer cells and neoplastic cells and cancer tissue samples as compared to non-tumor cells or normal adjacent tissue.