ORAI1-mediated calcium influx in lactation and in breast cancer.

  title={ORAI1-mediated calcium influx in lactation and in breast cancer.},
  author={Damara McAndrew and Desma M. Grice and Amelia A. Peters and Felicity M Davis and Teneale A Stewart and Michelle Rice and Chanel E. Smart and Melissa A Brown and Paraic A. Kenny and Sarah J. Roberts-Thomson and Gregory R Monteith},
  journal={Molecular cancer therapeutics},
  volume={10 3},
The entry of calcium into the mammary epithelial cell from the maternal plasma (i.e., calcium influx mechanisms) during lactation is poorly understood. As alterations in calcium channels and pumps are a key feature of some cancers, including breast cancer, understanding these calcium influx pathways may have significance beyond mammary biology. We show that the store-operated calcium influx protein, Orai1, is increased during lactation whereas the Orai1 activator Stim1, but not Stim2, is… CONTINUE READING
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