OPTIMIZER: a web server for optimizing the codon usage of DNA sequences

Abstract

OPTIMIZER is an on-line application that optimizes the codon usage of a gene to increase its expression level. Three methods of optimization are available: the 'one amino acid-one codon' method, a guided random method based on a Monte Carlo algorithm, and a new method designed to maximize the optimization with the fewest changes in the query sequence. One… (More)
DOI: 10.1093/nar/gkm219

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