OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors in rhesus macaques.

@article{Schwandt2011OPRM1GV,
  title={OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors in rhesus macaques.},
  author={Melanie L. Schwandt and Stephen G. Lindell and James Dee Higley and Stephen J. Suomi and Markus Heilig and Christina S. Barr},
  journal={Psychoneuroendocrinology},
  year={2011},
  volume={36 9},
  pages={
          1303-11
        }
}
The endogenous opioid system is involved in modulating a number of behavioral and physiological systems, including the hypothalamic-pituitary-adrenal (HPA) axis. In humans, a functional variant in the OPRM1 gene (OPRM1 A118G) is associated with a number of outcomes, including attenuated HPA axis responses to stress. A nonsynonymous variant (OPRM1 C77G) in the rhesus macaque has been shown to have similar effects in vivo to the human variant. The current study investigated whether OPRM1 C77G… CONTINUE READING
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