OPRM1 and CYP2B6 Gene Variants as Risk Factors in Methadone‐Related Deaths

@article{Bunten2010OPRM1AC,
  title={OPRM1 and CYP2B6 Gene Variants as Risk Factors in Methadone‐Related Deaths},
  author={Hannah Bunten and W J Liang and Derrick J. Pounder and Collin Seneviratne and David Osselton},
  journal={Clinical Pharmacology \& Therapeutics},
  year={2010},
  volume={88}
}
  • H. Bunten, W J Liang, +2 authors D. Osselton
  • Published 2010
  • Medicine
  • Clinical Pharmacology & Therapeutics
Methadone is a medication valued for its effectiveness in the treatment of heroin addiction; however, many fatal poisonings associated with its use have been reported over the years. We have examined the association between CYP2B6 and µ‐opioid receptor (OPRM1) gene variations and apparent susceptibility to methadone poisoning. Genomic DNA was extracted from postmortem whole blood of 40 individuals whose deaths were attributed to methadone poisoning. The presence of CYP2B6*4,*9, and *6 alleles… Expand
Interindividual variability in the prevalence of OPRM1 and CYP2B6 gene variations may identify drug-susceptible populations.
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The prevalence of CYP2B6 and μ-opioid receptor (OPRM1) gene variations were examined between a postmortem population where the deaths were associated with methadone and a live nondrug-using control population using Taqman™ SNP Genotyping assays. Expand
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Findings provide new insight to the fact that the interindividual variability of methadone dosage requirement is polygenetic and cannot be explained by a single-gene effect. Expand
SIMULTANEOUS DETECTION OF MULTIPLE POLYMORPHISMS IN CYP 2 B 6 AND OPMR 1 BY NESTED PCR : A GOOD APPROACH FOR PATIENTS ON METHADONE
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