OPG and sRANKL serum concentrations in osteopenic, postmenopausal women after 2-year genistein administration.

@article{Marini2008OPGAS,
  title={OPG and sRANKL serum concentrations in osteopenic, postmenopausal women after 2-year genistein administration.},
  author={Herbert R Marini and Letteria Minutoli and Francesca Polito and Alessandra Bitto and Domenica Altavilla and Marco Atteritano and Agostino Gaudio and Susanna Mazzaferro and Alessia Frisina and Nicola Frisina and Carla Lubrano and Michele Bonaiuto and Rosario D'Anna and Maria Letizia Cannata and Francesco Corrado and Francesco Cancellieri and Marianna Faraci and Rolando Marini and Elena Bianca Adamo and Steven J Wilson and Francesco Squadrito},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2008},
  volume={23 5},
  pages={715-20}
}
INTRODUCTION RANKL and its decoy receptor osteoprotegerin (OPG) constitute a complex physiological mediator system involved in the regulation of bone resorption and may be responsible for the homeostatic mechanism of normal bone remodeling. Genistein, an isoflavone representing 1-5% of total phytoestrogen content in soybean products, may positively regulate cellular bone metabolism, but its mechanism of action on bone is not yet fully understood. MATERIALS AND METHODS We studied the serum… CONTINUE READING

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