OPG and PgR show similar cohort specific effects as prognostic factors in ER positive breast cancer.

@article{Saenger2014OPGAP,
  title={OPG and PgR show similar cohort specific effects as prognostic factors in ER positive breast cancer.},
  author={Nicole Saenger and Eugen Ruckhaeberle and G. L. Bianchini and Tomas M. Heinrich and Karin Milde-Langosch and Volkmar Mueller and Achim Rody and Erich Franz Solomayer and Tanja N. Fehm and Uwe Holtrich and Sven Becker and Thomas Karn},
  journal={Molecular oncology},
  year={2014},
  volume={8 7},
  pages={1196-207}
}
The RANK/RANKL/OPG pathway is well known for bone destruction in skeletal metastases but has also been implicated in osteoclast-independent roles in tumorigenesis and de novo metastasis. Experimental data suggest contribution of progesterone to tumorigenesis may be mediated by RANKL. Importantly, modulation of this pathway became possible through the… CONTINUE READING