OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells.

@article{Kim2013OPB31121AN,
  title={OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells.},
  author={Mi Jung Kim and Hyun-Jin Nam and Hwang-phill Kim and S. -M. Han and Seock-Ah Im and T. -Y. Kim and Do-youn Oh and Yung-jue Bang},
  journal={Cancer letters},
  year={2013},
  volume={335 1},
  pages={145-52}
}
We investigated the mechanisms of action and antitumor effects of OPB-31121, a novel STAT3 inhibitor, in gastric cancer cells. OPB-31121 downregulated JAK2 and gp130 expression and inhibited JAK2 phosphorylation which leads to inhibition of STAT3 phosphorylation. OPB-31121 inhibited constitutively activated and IL-6-induced JAK/STAT signaling pathway. OPB-31121 decreased cell proliferation in both gastric cancer cells and in a xenograft model, induced the apoptosis of gastric cancer cells… CONTINUE READING

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