OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion

  title={OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion},
  author={Christian Frezza and Sara Cipolat and Olga Martins de Brito and Massimo Micaroni and Galina V. Beznoussenko and Tomasz Rudka and Davide Bartoli and Roman S. Polishuck and Nika N. Danial and Bart de Strooper and Luca Scorrano},
Mitochondria amplify activation of caspases during apoptosis by releasing cytochrome c and other cofactors. This is accompanied by fragmentation of the organelle and remodeling of the cristae. Here we provide evidence that Optic Atrophy 1 (OPA1), a profusion dynamin-related protein of the inner mitochondrial membrane mutated in dominant optic atrophy, protects from apoptosis by preventing cytochrome c release independently from mitochondrial fusion. OPA1 does not interfere with activation of… CONTINUE READING
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Dynamics of mitochondrial structure during apoptosis and the enigma of Opa1.

Biochimica et biophysica acta • 2009
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