OP0092 Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration and improves exercise tolerance

@article{Cavalli2017OP0092I3,
  title={OP0092 Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration and improves exercise tolerance},
  author={Giulio Cavalli and Dov B Ballak and Jj Justice and Kristen E. Boyle and Angelo D'Alessandro and Liesbeth Joosten and Lorenzo Dagna and Charles A Dinarello},
  journal={Annals of the Rheumatic Diseases},
  year={2017},
  volume={76},
  pages={90}
}
Background The IL-1 family cytokine interleukin 37 (IL-37) has broad anti-inflammatory effects and functions as a natural suppressor of innate inflammation and acquired immunity (1). We have reported that administration of recombinant human IL-37 to wild type mice or expression in mice transgenic for human IL-37 suppress proinflammatory cytokines and curb excessive inflammation in various conditions including inflammatory arthritis (2). Besides these anti-inflammatory effects, IL-37 also… CONTINUE READING