OP0023 Germinal and Somatic Genetic Variants of TNFAIP3 Promote Lymphomagenesis Process Complicating Primary Sjögren’s Syndrome

@article{Nocturne2013OP0023GA,
  title={OP0023 Germinal and Somatic Genetic Variants of TNFAIP3 Promote Lymphomagenesis Process Complicating Primary Sj{\"o}gren’s Syndrome},
  author={Ga{\'e}tane Nocturne and Saida Boudaoud and Corinne Miceli Richard and Say Viengchareun and Thierry Lazure and Joanne Nititham and Kimberly E. Taylor and Lindsey A. Criswell and Aihua Ma and Florence Busato and Judith Melki and Jean-Jacques Dubost and Eric Hachulla and Jacques-Eric Gottenberg and Marc Lomb{\`e}s and J{\"o}rg Tost and Xavier Mariette},
  journal={Annals of the Rheumatic Diseases},
  year={2013},
  volume={72},
  pages={A55 - A56}
}
Background The pathophysiology of lymphomas in auto immune disease (AID) involves persistent inflammation and activation of autoimmune B cells leading to NF-kB activation. The TNFAIP3 gene encodes the A20 protein, a central gatekeeper of NF-kB activation. Germinal abnormalities in TNFAIP3 have been associated with different AID and somatic mutations of the gene have been observed in several lymphoma subtypes, particularly MALT lymphoma, the lymphoma subtype most frequently associated with pSS…