ONYX-015 works synergistically with chemotherapy in lung cancer cell lines and primary cultures freshly made from lung cancer patients.

@article{You2000ONYX015WS,
  title={ONYX-015 works synergistically with chemotherapy in lung cancer cell lines and primary cultures freshly made from lung cancer patients.},
  author={Liang You and Cheng-Ta Yang and David Mark Jablons},
  journal={Cancer research},
  year={2000},
  volume={60 4},
  pages={1009-13}
}
p53 mutations and loss of heterozygosity (LOH) have been detected in >50% of lung cancers. Wild-type p53 can prevent replication of damaged DNA and promote apoptosis of cells with abnormal DNA. A human adenovirus, ONYX-015, which has a deletion in the E1B region, has shown tumor-specific cytolytic effect in tumor cells with nonfunctional p53 and antitumor efficacy that can be augmented by chemotherapeutic agents. A recent report from an independent group, however, indicates that wild-type p53… CONTINUE READING

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Neoplasm of the lung

  • J. D. Minna
  • Harrison’s Principles of Internal Medicine, Ed
  • 1998
2 Excerpts

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