ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis

@article{Miki2011ONO8130AS,
  title={ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis},
  author={Takahiro Miki and Maho Matsunami and Saori Nakamura and Hiroki Okada and Atsufumi Kawabata},
  journal={PAIN},
  year={2011},
  volume={152},
  pages={1373-1381}
}
Given the previous evidence for involvement of prostanoid EP1 receptors in facilitation of the bladder afferent nerve activity and micturition reflex, the present study investigated the effect of ONO-8130, a selective EP1 receptor antagonist, on cystitis-related bladder pain in mice. Cystitis in mice was produced by intraperitoneal administration of cyclophosphamide at 300mg/kg. Bladder pain-like nociceptive behavior and referred hyperalgesia were assessed in conscious mice. Phosphorylation of… CONTINUE READING
Highly Cited
This paper has 35 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

The Nonsteroidal Anti-inflammatory Drug Diclofenac Reduces Acid-Induced Heartburn Symptoms in Healthy Volunteers.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association • 2015

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Urothelium EP1 receptor facilitates the micturition reflex in mice.

Biomedical research • 2008
View 4 Excerpts
Highly Influenced

Deficits in visceral pain and referred hyperalgesia in Nav1.8 (SNS/PN3)-null mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2002
View 4 Excerpts
Highly Influenced

Role of mast cells and protease-activated receptor-2 in cyclooxygenase-2 expression in urothelial cells.

American journal of physiology. Regulatory, integrative and comparative physiology • 2009
View 2 Excerpts

An excitatory role for peripheral EP3 receptors in bladder afferent function.

American journal of physiology. Renal physiology • 2008
View 1 Excerpt