ONLINE MUTATION REPORT Molecular alterations in mitochondrial DNA of hepatocellular carcinomas: is there a correlation with clinicopathological profile?


M olecular defects in the mitochondrial genome responsible for a broad clinical spectrum of maternally inherited neuromuscular mitochondrial disorders have been documented extensively. 2 Mitochondrial dysfunction causes cellular degeneration, particularly in nerve and muscle cells that have a high demand for energy. The role of the mitochondria in apoptotic… (More)


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