ONCE-MONTHLY RIFAMPICIN PLUS DAILY DAPSONE IN INITIAL TREATMENT OF LEPROMATOUS LEPROSY

@article{Yawalkar1982ONCEMONTHLYRP,
  title={ONCE-MONTHLY RIFAMPICIN PLUS DAILY DAPSONE IN INITIAL TREATMENT OF LEPROMATOUS LEPROSY},
  author={S. J. Yawalkar and A. C. Mcdougall and J. Languillon and S S Ghosh and S K Hajra and Diltor Vladimir Ara{\'u}jo Opromolla and Claudio Joaquim Sampaio Tonello},
  journal={The Lancet},
  year={1982},
  volume={319},
  pages={1199-1202}
}
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28 Citations
Background Citations
5
Methods Citations
1

28 Citations

Treatment of leprosy
TLDR
Testing for recent nerve damage and treating it with steroids is essential and Dermatologists already have an important role in treating patients in the large Indian and Brazilian cities, and this is likely to increase as leprosy programmes are integrated into primary care.
NEW DEVELOPMENT IN LEPROSY CONTROL AND THE ISSUES OF INTEGRATION
TLDR
It is suggested that integration with the TB seroices might be possible about three years after the setting-up of multidrug therapy in any area, and full integration into PHC could be possible after about 10 years.
Uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): Results of an open label, randomized and controlled clinical trial, among multibacillary patients
TLDR
The hypothesis that UMDT is an acceptable option to be adopted in endemic countries to treat leprosy patients in the field worldwide is supported.
Considerations in the design of clinical trials for multibacillary leprosy treatment
In 1991, the World Health Assembly adopted a resolution to attain the goal of global elimination of leprosy as a public health problem by the year 2000, based on universal access to multidrug therapy…
An enhanced regimen as post-exposure chemoprophylaxis for leprosy: PEP++
TLDR
The Netherlands Leprosy Relief (NLR) is developing a multi-country study aiming to show that breaking the chain of transmission of M. leprae is possible, evidenced by a dramatic reduction in incidence.
Considerations on clinical trials of leprosy treatment: need of novel drug combinations
TLDR
To replace the standard WHO-MDT, the new combination must be the shortest, simplest and, consequently, most affordable treatment possible.
The management of leprosy
TLDR
An expert committee of the World Health Organization (WHO) has suggested combination chemotherapy in shorter courses to minimize the risk that resistance might develop.
The imperatives of leprosy treatment in the pre‐ and post‐global leprosy elimination era: Appraisal of changing the scenario to current status
TLDR
The progress made in the treatment of this neglected tropical disease from the time diaminodiphenylsulfone (dapsone) monotherapy was introduced in its management, to the rapidly changing situation following the advent of WHO‐recommended MDT and subsequently to short‐course newer drug regimens with the prime objective to eliminate/eradicate leprosy from the world.
Pharmacologic management of Mycobacterium ulcerans infection
TLDR
Pharmacological treatment of Buruli ulcer (Mycobacterium ulcerans infection; BU) is highly effective, as shown in two randomized trials in Africa, and an array of repurposed tuberculosis and leprosy drugs appears effective in vitro and in animal models.
Pitfalls in the diagnosis of leprous neuropathy: Lessons learnt from a University hospital in an endemic zone
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References

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TLDR
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Summary Continuous dietary administration of rifampin to mice with an established Mycobacterium leprae footpad infection reduced the bacillary solid ratio, with an estimated survival half-life of 5-6…
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