ONCE-MONTHLY RIFAMPICIN PLUS DAILY DAPSONE IN INITIAL TREATMENT OF LEPROMATOUS LEPROSY

@article{Yawalkar1982ONCEMONTHLYRP,
  title={ONCE-MONTHLY RIFAMPICIN PLUS DAILY DAPSONE IN INITIAL TREATMENT OF LEPROMATOUS LEPROSY},
  author={S. Yawalkar and A. Mcdougall and J. Languillon and S. Ghosh and C. J. Tonello},
  journal={The Lancet},
  year={1982},
  volume={319},
  pages={1199-1202}
}
In an international multicentre controlled single-blind trial of 93 previously untreated lepromatous leprosy patients the therapeutic effects of adding rifampicin, 450 mg/day orally or 1,200 mg once monthly in a single oral dose, to dapsone (50 mg/day orally) for the first 6 months of treatment were compared. Clinical and histopathological improvements and bacteriological regression, indicated by the decreases in the bacterial and morphological indices of the skin and nose-blow smears, were… Expand
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