ON G PROTEIN-COUPLED RECEPTORS The Histamine H 3 Receptor : Structure , Pharmacology , and Function

@inproceedings{NietoAlamilla2016ONGP,
  title={ON G PROTEIN-COUPLED RECEPTORS The Histamine H 3 Receptor : Structure , Pharmacology , and Function},
  author={Gustavo Nieto-Alamilla and Ricardo M{\'a}rquez-G{\'o}mez and Ana-Maricela Garc{\'i}a-G{\'a}lvez and Guadalupe-Elide Morales-Figueroa and Jos{\'e}-Antonio Arias-Monta{\~n}o},
  year={2016}
}
Among the four G protein–coupled receptors (H1–H4) identified as mediators of the biologic effects of histamine, the H3 receptor (H3R) is distinguished for its almost exclusive expression in the nervous system and the large variety of isoforms generated by alternative splicing of the corresponding mRNA. Additionally, it exhibits dual functionality as autoreceptor and heteroreceptor, and this enables H3Rs to modulate the histaminergic and other neurotransmitter systems. The cloning of the H3R… CONTINUE READING

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