OMEGA-3 LONG CHAIN POLYUNSATURATED FATTY ACIDS AS SENSITIZING 2 AGENTS AND MULTIDRUG RESISTANCE REVERTANTS IN CANCER THERAPY

@inproceedings{Corsetto2017OMEGA3LC,
  title={OMEGA-3 LONG CHAIN POLYUNSATURATED FATTY ACIDS AS SENSITIZING 2 AGENTS AND MULTIDRUG RESISTANCE REVERTANTS IN CANCER THERAPY},
  author={Paola Antonia Corsetto and Irma Colombo and Joanna Kopecka and Angela Maria Rizzo},
  year={2017}
}
The efficacy of chemotherapy depends on sensitivity and intrinsic or acquired drug 14 resistance of cancer cells. The n-3 long chain polyunsaturated fatty acids (n-3 LCPUFAs) are 15 considered chemosensitizing agents and revertants of multidrug resistance by pleiotropic 16 mechanisms. The specific mechanisms are not fully understood, but nowadays, it is widely accepted 17 that there are a complex network of mechanisms, including alteration in gene expression, 18 modulation of cellular… 
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