OMA1 mediates OPA1 proteolysis and mitochondrial fragmentation in experimental models of ischemic kidney injury.

@article{Xiao2014OMA1MO,
  title={OMA1 mediates OPA1 proteolysis and mitochondrial fragmentation in experimental models of ischemic kidney injury.},
  author={Xiao Xiao and Yan-zhong Hu and Pedro M Quiros and Qingqing Wei and Carlos L{\'o}pez-Ot{\'i}n and Zheng Bang Dong},
  journal={American journal of physiology. Renal physiology},
  year={2014},
  volume={306 11},
  pages={F1318-26}
}
Acute kidney injury (AKI) is associated with mitochondrial fragmentation, which contributes to mitochondrial damage and tubular cell apoptosis. Mitochondrial fragmentation involves the cleavage of both mitochondrial outer and inner membranes. Cleavage of the outer membrane results from Drp-1-mediated fission activation and Bak-promoted fusion arrest, but the molecular mechanism of inner membrane cleavage remains elusive. OMA1-mediated proteolysis of OPA1, a key inner membrane fusion protein… CONTINUE READING