OLIG2 is differentially expressed in pediatric astrocytic and in ependymal neoplasms

@inproceedings{Otero2010OLIG2ID,
  title={OLIG2 is differentially expressed in pediatric astrocytic and in ependymal neoplasms},
  author={Jos{\'e} Javier Otero and David H. Rowitch and Scott R. Vandenberg},
  booktitle={Journal of Neuro-Oncology},
  year={2010}
}
The bHLH transcription factor, OLIG2, is universally expressed in adult human gliomas and, as a major factor in the development of oligodendrocytes, is expressed at the highest levels in low-grade oligodendroglial tumors. In addition, it is functionally required for the formation of high-grade astrocytomas in a genetically relevant murine model. The pediatric gliomas have genomic profiles that are different from the corresponding adult tumors and accordingly, the expression of OLIG2 in non… CONTINUE READING