OL-protocadherin is essential for growth of striatal axons and thalamocortical projections

@article{Uemura2007OLprotocadherinIE,
  title={OL-protocadherin is essential for growth of striatal axons and thalamocortical projections},
  author={Masato Uemura and Shinsuke Nakao and Shintaro Suzuki and Masatoshi Takeichi and Shinji Hirano},
  journal={Nature Neuroscience},
  year={2007},
  volume={10},
  pages={1151-1159}
}
The ventral telencephalon in the embryonic brain is thought to provide guidance cues for navigation of thalamocortical axons, but the mechanisms involved remain largely elusive. OL-protocadherin (OL-pc), a member of the cadherin superfamily, is highly expressed by striatal neurons in the developing ventral telencephalon. Here we show that OL-pc–deficient (Pcdh10−/−) mice have defects in axon pathways through the ventral telencephalon; for example, thalamocortical and corticothalamic projections… CONTINUE READING