OK432-activated human dendritic cells kill tumor cells via CD40/CD40 ligand interactions.

@article{Hill2008OK432activatedHD,
  title={OK432-activated human dendritic cells kill tumor cells via CD40/CD40 ligand interactions.},
  author={Katy S. Hill and Fiona Errington and Lynette P. Steele and Alison Merrick and Ruth Morgan and Peter John Selby and Nikolaos T. Georgopoulos and Dearbhaile M O'Donnell and Alan A Melcher},
  journal={Journal of immunology},
  year={2008},
  volume={181 5},
  pages={3108-15}
}
In vivo, dendritic cells (DC) are programmed to orchestrate innate and adaptive immunity in response to pathogen-derived "danger" signals. Under particular circumstances, DC can also be directly cytotoxic against tumor cells, potentially allowing them to release tumor associated Ags from dying cells and then prime antitumor immunity against them. In this study, we describe the innate characteristics of DC (OK-DC) generated in vitro after exposure of immature human myeloid-derived DC to OK432, a… CONTINUE READING