OF4949, new inhibitors of aminopeptidase B. II. Elucidation of structure.

  title={OF4949, new inhibitors of aminopeptidase B. II. Elucidation of structure.},
  author={Shigeki Sano and Katsushige Ikai and Kazunori Katayama and Kazutoh Takesako and Terukazu Nakamura and Akiko Obayashi and Yohji Ezure and Hiroshi Enomoto},
  journal={The Journal of antibiotics},
  volume={39 12},
The structures of OF4949-I, II, III and IV were identified by analysis of the products of their chemical degradation and by 1H NMR, 13C NMR, and mass spectrometry. These compounds were new cyclic peptides containing diphenyl ether as a chromophore. OF4949-I had two amino acids, beta-hydroxy-L-asparagine and 4-methylisodityrosine. The structural differences between I and II and between III and IV lay solely in the diphenyl ether moiety; the phenolic hydroxyl group in II and IV was methylated in… CONTINUE READING

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