OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells.

@article{Navarro2012OCT4SOX2independentNA,
  title={OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells.},
  author={Pablo E. Navarro and Nicola Festuccia and Douglas Colby and Alessia Gagliardi and Nicholas P. Mullin and Wensheng Zhang and Violetta Karwacki-Neisius and Rodrigo Osorno and David Kelly and Morag Robertson and Ian Chambers},
  journal={The EMBO journal},
  year={2012},
  volume={31 24},
  pages={4547-62}
}
NANOG, OCT4 and SOX2 form the core network of transcription factors supporting embryonic stem (ES) cell self-renewal. While OCT4 and SOX2 expression is relatively uniform, ES cells fluctuate between states of high NANOG expression possessing high self-renewal efficiency, and low NANOG expression exhibiting increased differentiation propensity. NANOG, OCT4 and SOX2 are currently considered to activate transcription of each of the three genes, an architecture that cannot readily account for NANOG… CONTINUE READING
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