OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.

  title={OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.},
  author={Ligong Chen and Yan Shu and Xiaomin Liang and Eugene C Chen and Sook Wah Yee and Arik A. Zur and Shuanglian Li and Lu Xu and Kayvan R. Keshari and Michael Z. Lin and Huan-Chieh Chien and Youcai Zhang and Kari M. Morrissey and Jason Yingjie Liu and Jonathan M. L. Ostrem and Noah S Younger and John Kurhanewicz and Kevan M. Shokat and Kaveh Ashrafi and Kathleen M. Giacomini},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 27},
Organic cation transporter 1, OCT1 (SLC22A1), is the major hepatic uptake transporter for metformin, the most prescribed antidiabetic drug. However, its endogenous role is poorly understood. Here we show that similar to metformin treatment, loss of Oct1 caused an increase in the ratio of AMP to ATP, activated the energy sensor AMP-activated kinase (AMPK), and substantially reduced triglyceride (TG) levels in livers from healthy and leptin-deficient mice. Conversely, livers of human OCT1… CONTINUE READING
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Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

  • Y Shu
  • J Clin Invest 117(5):1422–1431
  • 2007
Highly Influential
8 Excerpts

Cellular and molecular mechanisms of metformin: An overview

  • B Viollet
  • Clin Sci ( Lond )
  • 2012
Highly Influential
5 Excerpts

Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents : The TONIC randomized controlled trial

  • JE Lavine
  • JAMA
  • 2011

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