OCRL controls trafficking through early endosomes via PtdIns4,5P₂-dependent regulation of endosomal actin.

@article{Vicinanza2011OCRLCT,
  title={OCRL controls trafficking through early endosomes via PtdIns4,5P₂-dependent regulation of endosomal actin.},
  author={Mariella Vicinanza and Antonella Di Campli and Elena Polishchuk and Michele Santoro and Giuseppe Di Tullio and Anna Godi and Elena Levtchenko and Maria Giovanna De Leo and Roman Polishchuk and Lisette Sandoval and M P Marzolo and Maria Antonietta De Matteis},
  journal={The EMBO journal},
  year={2011},
  volume={30 24},
  pages={4970-85}
}
Mutations in the phosphatidylinositol 4,5-bisphosphate (PtdIns4,5P(2)) 5-phosphatase OCRL cause Lowe syndrome, which is characterised by congenital cataracts, central hypotonia, and renal proximal tubular dysfunction. Previous studies have shown that OCRL interacts with components of the endosomal machinery; however, its role in endocytosis, and thus the pathogenic mechanisms of Lowe syndrome, have remained elusive. Here, we show that via its 5-phosphatase activity, OCRL controls early endosome… CONTINUE READING
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