OCA-B integrates B cell antigen receptor-, CD40L- and IL 4-mediated signals for the germinal center pathway of B cell development.

@article{Qin1998OCABIB,
  title={OCA-B integrates B cell antigen receptor-, CD40L- and IL 4-mediated signals for the germinal center pathway of B cell development.},
  author={Xiaoli Qin and Amy Reichlin and Yan Luo and Robert G Roeder and Michel C. Nussenzweig},
  journal={The EMBO journal},
  year={1998},
  volume={17 17},
  pages={5066-75}
}
Many of the key decisions in lymphocyte differentiation and activation are dependent on integration of antigen receptor and co-receptor signals. Although there is significant understanding of these receptors and their signaling pathways, little is known about the molecular requirements for signal integration at the level of activation of gene expression. Here we show that in primary B cells, expression of the B-cell specific transcription coactivator OCA-B (also known as OBF-1 or Bob-1) is… CONTINUE READING

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