OBIF, an osteoblast induction factor, plays an essential role in bone formation in association with osteoblastogenesis.

@article{Mizuhashi2012OBIFAO,
  title={OBIF, an osteoblast induction factor, plays an essential role in bone formation in association with osteoblastogenesis.},
  author={Koji Mizuhashi and Takashi Kanamoto and Masako Ito and Takeshi Moriishi and Yuki Muranishi and Yoshihiro Omori and Koji Terada and Toshihisa Komori and Takahisa Furukawa},
  journal={Development, growth & differentiation},
  year={2012},
  volume={54 4},
  pages={
          474-80
        }
}
In vertebrate bone formation, the functional mechanisms of transcription factors in osteoblastic differentiation have been relatively well elucidated; however, the exact roles of cell-extrinsic molecules are less clear. We previously identified human and mouse Obif, an osteoblast induction factor, also known as Tmem119, which encodes a single transmembrane protein. OBIF is predominantly expressed in osteoblasts in mouse. While exogenous Obif expression stimulated osteoblastic differentiation… CONTINUE READING
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