OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype.

@article{Wang1998OBRbGT,
  title={OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype.},
  author={May-yun Wang and Kazunori Koyama and Michio Shimabukuro and Christopher B. Newgard and Roger H. Unger},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 2},
  pages={
          714-8
        }
}
In obese Zucker diabetic fatty (ZDF) rats with mutant leptin receptors, pancreatic islets have an approximately 50-fold increase in fat (TG), overproduce nitric oxide (NO), and lack a normal proinsulin mRNA response to fatty acids. We overexpressed the wild-type full-length "b" isoform of the leptin receptor (OB-Rb) in ZDF islets by perfusing ZDF pancreata with recombinant adenovirus containing the cDNA encoding OB-Rb. In cultured islets isolated from these animals, leptin lowered islet TG by… CONTINUE READING
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Wang et al

  • Zhou, M.Y.T. Shimabukuro, K. Koyama, Y. Lee, Wang, Medical Sciences
  • Proc. Natl. Acad. Sci. USA 95 () 717 M.-Y…
  • 1997
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Wang et al

  • Unger, 6 R.H.TrendsEndocrinol.Metab., 276–282. 718 Medical Sciences
  • Proc. Natl. Acad. Sci. USA 95
  • 1998