OASL-a new player in controlling antiviral innate immunity.

  title={OASL-a new player in controlling antiviral innate immunity.},
  author={Jianzhong Zhu and Arundhati Sengupta Ghosh and Saumendra N Sarkar},
  journal={Current opinion in virology},
The cellular innate immune system plays a crucial role in mounting the initial resistance to virus infection. It is comprised of various pattern-recognition receptors that induce type I interferon production, which further shapes the adaptive immunity. However, to overcome this resistance and promote replication, viruses have evolved mechanisms to evade this host innate immune response. Here we discuss a recently described mechanism of boosting the innate immunity by oligoadenylate synthetase… CONTINUE READING
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