O6-methylguanine DNA methyltransferase as a promising target for the treatment of temozolomide-resistant gliomas

@inproceedings{Fan2013O6methylguanineDM,
  title={O6-methylguanine DNA methyltransferase as a promising target for the treatment of temozolomide-resistant gliomas},
  author={C-H Fan and W-L Liu and Heng Cao and C. X. Wen and Lingming Chen and G Jiang},
  booktitle={Cell Death and Disease},
  year={2013}
}
Temozolomide (TMZ) is an alkylating agent currently used as first-line therapy for gliomas treatment due to its DNA-damaging effect. However, drug resistance occurs, preventing multi-cycle use of this chemotherapeutic agent. One of the major mechanisms of cancer drug resistance is enhanced activity of a DNA repair enzyme, O6-methylguanine-DNA-methyltransferase (MGMT), which counteracts chemotherapy-induced DNA alkylation and is a key component of chemoresistance. MGMT repairs TMZ-induced DNA… CONTINUE READING