O6-alkylguanine-DNA alkyltransferase activity in schistosomiasis-associated human bladder cancer.

@article{Badawi1994O6alkylguanineDNAAA,
  title={O6-alkylguanine-DNA alkyltransferase activity in schistosomiasis-associated human bladder cancer.},
  author={Alaa F Badawi and D. P. Cooper and Mostafa Hassan Mostafa and T. E. Aboul-Azm and Rochelle Barnard and G. P. Margison and Peter J. O'connor},
  journal={European journal of cancer},
  year={1994},
  volume={30A 9},
  pages={
          1314-9
        }
}
O6-Alkylguanine-DNA-alkyltransferase (ATase) activity was measured in extracts of 55 bladder tissue samples (46 tumour and nine uninvolved mucosal tissue) from Egyptian patients with schistosome-associated bladder carcinoma. Activity varied from 2.0 to 16.2 fmole ATase/microgram DNA (mean +/- S.D.; 5.6 +/- 4.0) or from 28 to 351 fmole ATase/mg (117 +/- 71). ATase levels in schistosome-associated bladder cancer tissues (5.6 +/- 4.0 fmole ATase/microgram DNA) tended to be lower than those… CONTINUE READING
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