O6-Methylguanine-DNA methyltransferase inactivation and chemotherapy.

  title={O6-Methylguanine-DNA methyltransferase inactivation and chemotherapy.},
  author={Barbara Verbeek and Thomas D. Southgate and David Edward Gilham and G. P. Margison},
  journal={British medical bulletin},
INTRODUCTION Alkylating agents are frequently used in the chemotherapy of many types of cancer. This group of drugs mediates cell death by damaging DNA and therefore, understandably, cellular DNA repair mechanisms can influence both their antitumour efficacy and their dose-limiting toxicities. SOURCES OF DATA This review focuses on the mechanism of action of the DNA repair protein, O(6)-methylguanine-DNA methyltransferase (MGMT) and its exploitation in cancer therapy and reviews the current… CONTINUE READING