O4.1. GENETIC VULNERABILITY TO DUSP22 PROMOTOR HYPERMETHYLATION IS INVOLVED IN THE RELATION BETWEEN IN UTERO FAMINE EXPOSURE AND SCHIZOPHRENIA

@inproceedings{Boks2018O41GV,
  title={O4.1. GENETIC VULNERABILITY TO DUSP22 PROMOTOR HYPERMETHYLATION IS INVOLVED IN THE RELATION BETWEEN IN UTERO FAMINE EXPOSURE AND SCHIZOPHRENIA},
  author={Marco P M Boks and L. C. Houtepen and Zhenzhuang Xu and Yujie He and Gianluca Ursini and Adam X Maihofer and Prashanth Rajarajan and Qiong Yu and Huan Xu and Yang Wu and Shoulin Wang and Jing Pei Shi and Hilleke E Hulshoff Pol and Eric E Strengman and Bart P F Rutten and Andrew E. Jaffe and Joel Edward Kleinman and Dewleen G. Baker and Elly M Hol and Schahram Akbarian and Caroline M Nievergelt and Lot D. de Witte and Christiaan H Vinkers and Daniel R. Weinberger and Jinyuan Yu and Ren{\'e} S. Kahn},
  booktitle={npj Schizophrenia},
  year={2018}
}
Epigenetic changes may account for the doubled risk to develop schizophrenia in individuals exposed to famine in utero. We therefore investigated DNA methylation in a unique sample of patients and healthy individuals conceived during the great famine in China. Subsequently, we examined two case-control samples without famine exposure in whole blood and brain tissue. To shed light on the causality of the relation between famine exposure and DNA methylation, we exposed human fibroblasts to… CONTINUE READING
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