O2 and rat pulmonary artery tone: effects of endothelium, Ca2+, cyanide, and monocrotaline.

@article{Mathew1991O2AR,
  title={O2 and rat pulmonary artery tone: effects of endothelium, Ca2+, cyanide, and monocrotaline.},
  author={Rajamma Mathew and Theresa Burke-Wolin and Michael H. Gewitz and Michael S. Wolin},
  journal={Journal of applied physiology},
  year={1991},
  volume={71 1},
  pages={
          30-6
        }
}
The present study examines the influence of the endothelium (E), Ca2+ concentration, cyanide and monocrotaline (MCT) pretreatment on the responses of isolated rat hilar pulmonary arterial rings (PA) to hypoxia. In PA precontracted with phenylephrine, hypoxia induced an initial E-dependent relaxation phase followed by an E-independent transient contraction and a final relaxation. An increase in Ca2+ concentration from 1.5 to 2.5 mM produced an E-dependent reduction in tone generation under O2… CONTINUE READING
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Hypoxic pulmonary vasoconstriction.

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Inhibition of NOS enhances pulmonary vascular changes in stroke-prone spontaneously hypertensive rats.

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