O2- and NO-sensing mechanism through the DevSR two-component system in Mycobacterium smegmatis.

@article{Lee2008O2AN,
  title={O2- and NO-sensing mechanism through the DevSR two-component system in Mycobacterium smegmatis.},
  author={Jin-Mok Lee and Ha Yeon Cho and Hyo Je Cho and In-Jeong Ko and Sae Woong Park and Hyung-Suk Baik and Jee-Hyun Oh and Chi-yong Eom and Young Min Kim and Beom Sik Kang and Jeong-Il Oh},
  journal={Journal of bacteriology},
  year={2008},
  volume={190 20},
  pages={
          6795-804
        }
}
The DevS histidine kinase of Mycobacterium smegmatis contains tandem GAF domains (GAF-A and GAF-B) in its N-terminal sensory domain. The heme iron of DevS is in the ferrous state when purified and is resistant to autooxidation from a ferrous to a ferric state in the presence of O(2). The redox property of the heme and the results of sequence comparison analysis indicate that DevS of M. smegmatis is more closely related to DosT of Mycobacterium tuberculosis than DevS of M. tuberculosis. The… CONTINUE READING

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