O10.6 A Potent Combination Microbicide Gel Inhibits SHIV-RT, HSV-2 and HPV Infections in Vivo

@article{Kizima2013O106AP,
  title={O10.6 A Potent Combination Microbicide Gel Inhibits SHIV-RT, HSV-2 and HPV Infections in Vivo},
  author={L. Kizima and A. Rodr{\'i}guez and Jessica Kenney and M. Hsu and Nina Derby and O. Mizenina and Radhika Menon and T. Zydowsky and M. Robbiani and J. Fern{\'a}ndez-Romero},
  journal={Sexually Transmitted Infections},
  year={2013},
  volume={89},
  pages={A45 - A46}
}
  • L. Kizima, A. Rodríguez, +7 authors J. Fernández-Romero
  • Published 2013
  • Medicine
  • Sexually Transmitted Infections
  • Background HIV acquisition is fueled by infection with HSV-2 and HPV. Microbicides that target all three STIs may more effectively limit HIV incidence. We previously showed that a gel containing the NNRTI MIV-150, zinc acetate (Z) and carrageenan (C, MZC) significantly protected macaques from vaginal SHIV-RT challenge, while ZC also protected mice against HSV-2 vaginally and rectally. Here we evaluate a new formulation of MZC optimised for clinical use against SHIV-RT, HSV-2, and HPV. Methods… CONTINUE READING