O-methylation of simple phenols in the rat.

  title={O-methylation of simple phenols in the rat.},
  author={Olav M. Bakke},
  journal={Acta pharmacologica et toxicologica},
  volume={28 1},
  • O. Bakke
  • Published 13 March 2009
  • Chemistry
  • Acta pharmacologica et toxicologica
Eleven simple mono-, di- and thihydric phenols were given by stomach tube at a dose of 100 mg/kg body weight. The subsequent 48-hour urines were hydrolyzed, extracted and analyzed by thin-layer and gas chromatography and by infrared spectrophotometry. The mean extent of direct O-methylation was 6.9% with catechol, 6.0% with 4-methylcatechol, 8.9% with 4-ethylcatechol and 6.2% with pyrogallol. The preferred site of methylation was the middle hydroxyl group of pyrogallol and the meta hydroxyl… 
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