O-mannosyl glycans: from yeast to novel associations with human disease.

  title={O-mannosyl glycans: from yeast to novel associations with human disease.},
  author={Tobias Willer and Mar{\'i}a Del Carmen Valero and Widmar Tanner and Jes{\'u}s Cruces and Sabine Strahl},
  journal={Current opinion in structural biology},
  volume={13 5},
In yeasts and other fungi, O-mannosyl glycans constitute a major protein modification that is essential for cell viability. For several decades, protein O-mannosylation was considered a yeast-specific modification. Thus, it was especially interesting when it became evident that O-mannosyl glycans in mammals are not as rare as previously thought. O-mannosyl glycans are abundant in the mammalian brain and are also an abundant modification of alpha-dystroglycan, a component of the dystrophin… CONTINUE READING


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