O-linked β-N-acetylglucosaminidase inhibitor attenuates β-amyloid plaque and rescues memory impairment.

@article{Kim2013OlinkedI,
  title={O-linked β-N-acetylglucosaminidase inhibitor attenuates β-amyloid plaque and rescues memory impairment.},
  author={Chaeyoung Kim and Dong Woo Nam and Sang Yoon Park and Hyundong Song and Hyun Seok Hong and Jung Hyun Boo and Eun Sun Jung and Yoonhee Kim and Ju Yuel Baek and Kwan Soo Kim and Jin won Cho and Inhee Mook-jung},
  journal={Neurobiology of aging},
  year={2013},
  volume={34 1},
  pages={275-85}
}
Deposition of β-amyloid (Aβ) as senile plaques and disrupted glucose metabolism are two main characteristics of Alzheimer's disease (AD). It is unknown, however, how these two processes are related in AD. Here we examined the relationship between O-GlcNAcylation, which is a glucose level-dependent post-translational modification that adds O-linked β-N-acetylglucosamine (O-GlcNAc) to proteins, and Aβ production in a mouse model of AD carrying 5XFAD genes. We found that 1,2-dideoxy-2'-propyl-α-d… CONTINUE READING
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