O-glycosylation pathway for mucin-type glycoproteins.

  title={O-glycosylation pathway for mucin-type glycoproteins.},
  author={Kermit L. Carraway and Stephen Hull},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={10 4},
O-glycosylation is the post-translational process whereby carbohydrate is added to hydroxylated amino acids of proteins. The major O-glycosylation pathway in animal cells is involved in the synthesis of oligosaccharides linked by N-acetylgalactosamine to serine or threonine residues in 'mucin-type' proteins or their analogs. In this review, we discuss the evidence for the cellular localization of the biosynthetic steps in this pathway and propose a simplified, consensus version. We also propose… CONTINUE READING


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