O-demethylation of tramadol in the first months of life

  title={O-demethylation of tramadol in the first months of life},
  author={Karel Allegaert and John N. van den Anker and Ren{\'e} Verbesselt and Jan de Hoon and Christine Vanhole and D Tibboel and Hugo Devlieger},
  journal={European Journal of Clinical Pharmacology},
Assess in vivo O-demethylation activity in the first months of life. Time–concentration profiles of tramadol (M) and O-demethyl tramadol (M1) in plasma and urine were simultaneously collected in the first 24 h of continuous intravenous tramadol administration in neonates and young infants. M and M1 were determined by high performance liquid chromatography… CONTINUE READING