O-carboxymethyl chitosan nanoparticles for metformin delivery to pancreatic cancer cells.

@article{Snima2012OcarboxymethylCN,
  title={O-carboxymethyl chitosan nanoparticles for metformin delivery to pancreatic cancer cells.},
  author={Kaniyampadi Sreenivasan Snima and R Jayakumar and A G Unnikrishnan and Shantikumar Vasudevan Nair and Vinoth-Kumar Lakshmanan},
  journal={Carbohydrate polymers},
  year={2012},
  volume={89 3},
  pages={1003-7}
}
In this work we developed metformin loaded O-carboxymethyl chitosan (O-CMC) nanoparticles (NPs) by ionic-gelation method. The prepared NPs of 240 ± 50 nm size with spherical morphology exhibited a pH sensitive release of metformin in vitro. Cytotoxicity studies showed that the drug-incorporated NPs induced significant toxicity on pancreatic cancer cells (MiaPaCa-2) compared to normal cells (L929). Metformin loaded NPs exhibited nonspecific internalization by normal and pancreatic cancer cells… CONTINUE READING

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