O- and N-demethylation of Venlafaxine In Vitro by Human Liver Microsomes and by Microsomes from cDNA-Transfected Cells: Effect of Metabolic Inhibitors and SSRI Antidepressants

@article{Fogelman1999OAN,
  title={O- and N-demethylation of Venlafaxine In Vitro by Human Liver Microsomes and by Microsomes from cDNA-Transfected Cells: Effect of Metabolic Inhibitors and SSRI Antidepressants},
  author={Steven M. Fogelman and Juergen Schmider and Karthik Venkatakrishnan and Lisa L. von Moltke and Jerold S. Harmatz and Richard I. Shader and David J Greenblatt},
  journal={Neuropsychopharmacology},
  year={1999},
  volume={20},
  pages={480-490}
}
The biotransformation of venlafaxine (VF) into its two major metabolites, O-desmethylvenlafaxine (ODV) and N-desmethylvenlafaxine (NDV) was studied in vitro with human liver microsomes and with microsomes containing individual human cytochromes from cDNA-transfected human lymphoblastoid cells. VF was coincubated with selective cytochrome P450 (CYP) inhibitors and several selective serotonin reuptake inhibitors (SSRIs) to assess their inhibitory effect on VF metabolism. Formation rates for ODV… CONTINUE READING
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