O-acetylated sialic acid as a distinct marker for differentiation between several leukemia erythrocytes

  title={O-acetylated sialic acid as a distinct marker for differentiation between several leukemia erythrocytes},
  author={G. Sen and M. Chowdhury and C. Mandal},
  journal={Molecular and Cellular Biochemistry},
  • G. Sen, M. Chowdhury, C. Mandal
  • Published 2004
  • Biology, Medicine
  • Molecular and Cellular Biochemistry
  • AchatininH (ATNH)is a lectin, isolated from the hemolymph ofAchatina fulica snail, which has been shown to have narrow specificity towards 9-O-acetyl sialic acid. Usually ATNH does not agglutinate normal human erythrocytes, however, it is capable of agglutinating erythrocytes of patients suffering from acute lymphocytic and acute myelogenous leukemia. Determination of binding constants, numbers of binding sites and lectin overlay experiments using patients' erythrocytes ghost, have suggested… CONTINUE READING
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