O-Mannosylation in Candida albicans Enables Development of Interkingdom Biofilm Communities

  title={O-Mannosylation in Candida albicans Enables Development of Interkingdom Biofilm Communities},
  author={Lindsay C. Dutton and Angela H Nobbs and Katy A. Jepson and Mark A. Jepson and M. Margaret Vickerman and Sami Aqeel Alawfi and Carol A Munro and Richard J Lamont and Howard F Jenkinson},
Candida albicans is a fungus that colonizes oral cavity surfaces, the gut, and the genital tract. Streptococcus gordonii is a ubiquitous oral bacterium that has been shown to form biofilm communities with C. albicans. Formation of dual-species S. gordonii-C. albicans biofilm communities involves interaction of the S. gordonii SspB protein with the Als3 protein on the hyphal filament surface of C. albicans. Mannoproteins comprise a major component of the C. albicans cell wall, and in this study… CONTINUE READING
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