O-GlcNAcylation of YY1 stimulates tumorigenesis in colorectal cancer cells by targeting SLC22A15 and AANAT.

@article{Zhu2019OGlcNAcylationOY,
  title={O-GlcNAcylation of YY1 stimulates tumorigenesis in colorectal cancer cells by targeting SLC22A15 and AANAT.},
  author={Guoqing Zhu and Ming-ping Qian and Liesheng Lu and Yan Chen and Xiao Qian Zhang and Qi Wu and Ya Liu and Zhixuan Bian and Yueyue Yang and Susu Guo and Jiayi Wang and Qiuhui Pan and Fenyong Sun},
  journal={Carcinogenesis},
  year={2019}
}
Emerging studies have revealed that O-GlcNAcylation plays pivotal roles in the tumorigenesis of colorectal cancers. However, the underlying mechanism still remains largely unknown. Here, we demonstrated that YY1 was O-GlcNAcylated by OGT and O-GlcNAcylation of YY1 could increase the protein expression by enhancing its stability. O-GlcNAcylation facilitated transformative phenotypes of CRC cell in a YY1-dependent manner. Also, O-GlcNAcylation stimulates YY1-dependent transcriptional activity… 
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