O-GlcNAcylation and cardiovascular disease.

  title={O-GlcNAcylation and cardiovascular disease.},
  author={JaLessa N Wright and Helen E Collins and Adam R. Wende and John C. Chatham},
  journal={Biochemical Society transactions},
  volume={45 2},
The post-translational modification of serine and threonine residues of proteins found in numerous subcellular locations by O-linked N-acetylglucosamine (O-GlcNAc) is emerging as a key mediator of many cardiovascular pathophysiological processes. Early studies implicated increased protein O-GlcNAcylation as contributing to the cardiovascular complications associated with diabetes, whereas subsequent studies demonstrated that acute increases in O-GlcNAc levels were protective against ischemia… 

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