O-GlcNAcylation Increases ChREBP Protein Content and Transcriptional Activity in the Liver

@inproceedings{Guinez2011OGlcNAcylationIC,
  title={O-GlcNAcylation Increases ChREBP Protein Content and Transcriptional Activity in the Liver},
  author={C{\'e}line Guinez and Ga{\"e}lle Filhoulaud and Fadila Rayah-Benhamed and Solenne Marmier and C{\'e}line Dubuquoy and Renaud Dentin and Marthe Moldes and Anne-Françoise Burnol and Xiaoyong Yang and Tony Lefebvre and Jean Girard and Catherine Postic},
  booktitle={Diabetes},
  year={2011}
}
OBJECTIVE Carbohydrate-responsive element-binding protein (ChREBP) is a key transcription factor that mediates the effects of glucose on glycolytic and lipogenic genes in the liver. We have previously reported that liver-specific inhibition of ChREBP prevents hepatic steatosis in ob/ob mice by specifically decreasing lipogenic rates in vivo. To better understand the regulation of ChREBP activity in the liver, we investigated the implication of O-linked β-N-acetylglucosamine (O-GlcNAc or O… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 51 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver.

Proceedings of the National Academy of Sciences of the United States of America • 2003
View 4 Excerpts
Highly Influenced

A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver.

Proceedings of the National Academy of Sciences of the United States of America • 2001
View 3 Excerpts
Highly Influenced

Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP).

Biochemical and biophysical research communications • 2010
View 2 Excerpts

Similar Papers

Loading similar papers…